Experimental infections with African trypanosomes. IV. Immunization of cattle with gamma-irradiated Trypanosoma rhodesiense.

WELLDE, B. T., DUXBURY, R. E., SADUN, E. H., LANGBEHN, H. R., LGTZSCH, R., DEINDL, G., AND WARUI, G. 1973. Experimental infections with African trypanosomes: IV. Immunization of cattle with gamma-irradiated Trypanosoma rhodesiense. Exjerimental Parasitology 34, 62-68. Cattle immunized with gamma-irradiated Trypanosoma rhodesiense were protected against a challenge inoculation’ of unirradiated trypanosomes given 1 wk later. These animals were still resistant when rechallenged after 8 mo and some residual immunity persisted for 14 mo after immunization. Animals which had undergone self-cure after infection were resistant when challenged 14 mo later. No resistance was observed in animals challenged with a heterologous strain of T. rJzodesien.re. The infections observed in unprotected1 bovines were of a mild nature. Leukopenia and fever were common early in the course of infection, but no anemia was evident at any time. INDEX DESCRIPTIONS : Trypanosoma rhodesiense ; Immunization ; Cattle ; Gamma radiation.